Know Thy Ancestors to Know Thyself: Improving Our Understanding of the Human Genome Using Paleogenomics

Thursday, March 9, 2017 -
1:30pm to 2:30pm
Biotechnology Center Auditorium, 425 Henry Mall

Speaker Name: 

Mathieu Blancette, Associate Professor, Computer Science

Speaker Institution: 

McGill University




Abstract: I will first discuss how the genomes of ancestral mammalian species can be reconstructed with surprisingly high accuracy from the genomes of extant species. I will then present how inferred ancestral sequences can be used to improve the detection of ancient evolutionary events such as transposable element and pseudogene insertions that have shaped mammalian genomes. This information can be exploited by statistical and machine learning algorithms to improve the accuracy of transcription factor binding site and micro-RNA target site prediction.