Multi-cellular Interactions in High Grade Serous Ovarian Cancer

Tuesday, November 29, 2016 -
4:00pm to 5:00pm
Biotechnology Center Auditorium, 425 Henry Mall

Speaker Name: 

Pamela Kreeger

Speaker Institution: 

Associate Professor, Departments of Biomedical Engineering; Cell & Regenerative Medicine, UW-Madison




High grade serous ovarian cancer has a mortality rate of nearly 70%, primarily due to the late stage at which it is diagnosed and the lack of specific therapies. We are developing in vitro models that incorporate multiple components of the tumor microenvironment in order to examine how cell-cell interactions impact disease progression and identify therapeutic targets. Ongoing projects include systems to analyze how macrophages, adipocytes, and the extracellular matrix influence the process of metastasis and resistance to chemotherapy. Given the complex nature of these interactions, our lab relies on modeling methods from systems biology to analyze these systems and identify key regulators to control tumor progression.