Alzheimer’s disease (AD) is the most common form of dementia, currently affecting over 5 million Americans. It is the sixth leading cause of death in the United States and the only of the top 10 causes of death with no way to prevent, cure, or impede its progression. Individuals with a family history of AD are at increased risk for developing the disease. The e4 allele of the apolipoprotein E (APOE) gene is a well-established risk factor. Genome-wide association studies (GWAS) have identified 19 additional genetic regions that are associated with AD. More recently, genomic sequencing studies have identified additional low frequency variants with a more substantial effect on risk for AD. Additional ‘omics studies of AD are being performed, including one by our group, requiring novel approaches to integrate all these data. Some examples of these approaches will be presented along with preliminary results.