Crystallography as a method of imaging molecule continues to play a dominant role. The process involves reconstructing an electron density map of the target molecule but only half of the needed information is available from the crystalline diffraction pattern. An iterative transform method proposed previously for direct phasing of high solvent-content protein crystals has been developed for enhancing solutions to the phase problem in protein crystallography. In favorable cases, protein structures can be solved directly from native diffraction patterns using this computational algorithm. Other new methods will also be described.