Health care choices are made based on results of large-scale studies. The care you receive is therefore based on what works for most people, not necessarily what will work for you. However, massive datasets of patient records are increasingly being mined to allow personalized health care decision making. This talk will highlight work by our group that addresses the following questions: How can a person choose the best lifestyle choices to minimize the risk of heart disease? How can a nurse minimize a child's distress during a painful medical procedure? And, how can a physician choose the best diagnostic test to reach a fast, cheap, and correct diagnosis?